The jury is in : p 73 is a tumor suppressor after all Jennifer
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References http://genesdev.cshlp.org/content/22/19/2591.full.html#related-urls Article cited in: http://genesdev.cshlp.org/content/22/19/2591.full.html#ref-list-1 This article cites 40 articles, 15 of which can be accessed free at: Related Content Genes Dev. October 1, 2008 22: 2677-2691 Richard Tomasini, Katsuya Tsuchihara, Margareta Wilhelm, et al. suppressor functions TAp73 knockout shows genomic instability with infertility and tumor
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The jury is in: p73 is a tumor suppressor after all.
While p53 has been extensively characterized as a tumor suppressor, it has been more difficult to determine whether p63 and/or p73 play a similar role. Every system in which these family members have been studied, from cells to animal models to human tissues, seems to create more questions than answers. Tomasini and colleagues (2677-2691) demonstrate that one isoform of p73 is responsible for p...
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